INDEPENDENT ASSESSMENT OF IN VITRO TOXICOLOGY PACKAGES

 

The data obtained from using in vitro toxicology methods can be difficult to evaluate and interpret, and to relate to more-conventional toxicology outcomes, by using prediction models.

Combes Consulting offers expert and independent judgement of the results of such testing methods, and advice as to how they contribute to the overall safety assessment of the test material (s) concerned.

Selected publications

Combes, R. & Balls, M. (2005). Intelligent testing strategies for chemicals testing 末 A case of more haste, less speed? ATLA 33, 289-297.

Grindon, C., Combes, R., Cronin, M.T.D., Roberts, D.W. & Garrod, J. (2006). Integrated decision-tree testing strategies for environmental toxicity with respect to the requirements of the EU REACH legislation. ATLA 34, 651-664.

Bhogal, N. & Combes, R. (2006). The UK Food Standards Agency Draft Report on Variability and Uncertainty in Toxicology: A Response by FRAME. ATLA 34, 539-544.

Grindon, C., Combes, R., Cronin, M.T.D., Roberts, D.W. & Garrod, J.F. (2007). Integrated decision-tree testing strategies for skin corrosion and irritation with respect to the requirements of the EU REACH legislation. ATLA 35, 673末682.

Grindon, C., Combes, R., Cronin, M.T.D., Roberts, D.W. & Garrod, J.F. (2007). An integrated decision-tree testing strategy for skin sensitisation with respect to the requirements of the EU REACH legislation. ATLA 35, 683末697.

Combes, R., Grindon, C., Cronin, M.T.D., Roberts, D.W. & Garrod, J. (2007). Proposed integrated decision-tree testing strategies for mutagenicity and carcinogenicity in relation to the EU REACH legislation. ATLA 35, 267-287.

Combes, R., Grindon, C., Cronin, M.T.D., Roberts, D.W. & Garrod, J.F. (2008). Integrated decision-tree testing strategies for acute systemic toxicity and toxicokinetics with respect to the requirements of the EU REACH legislation. ATLA 36, 45末63.

Grindon, C., Combes, R., Cronin, M.T.D., Roberts, D.W. & Garrod, J.F. (2008). Integrated decision-tree testing strategies for developmental and reproductive toxicity with respect to the requirements of the EU REACH legislation. ATLA 36, 65末80.

Combes, R., Grindon, C., Cronin, M.T.D., Roberts, D.W. & Garrod, J.F. (2008). Integrated decision-tree testing strategies for acute systemic toxicity and toxicokinetics with respect to the requirements of the EU REACH legislation. ATLA 36, 45末63.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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